DSpace Colección :https://repositorio.unimoron.edu.ar/handle/10.34073/2042024-03-03T13:33:26Z2024-03-03T13:33:26ZBilateral ablation of the vomeronasal organs produces dramatic changes in the EEG of the main olfactory system during paradoxical sleepCervino, ClaudioIodice, Omarhttps://repositorio.unimoron.edu.ar/handle/10.34073/3082023-03-14T13:43:14Z2023-03-01T00:00:00ZTítulo : Bilateral ablation of the vomeronasal organs produces dramatic changes in the EEG of the main olfactory system during paradoxical sleep
Autor : Cervino, Claudio; Iodice, Omar
Resumen : Background: The vomeronasal organ (VNO) plays an important role in reproductive physiology, behavior, sexual behavior and aggression.
Objective: The aim is to report a surprising effect of the removal of the VNO on the cortical electrical activity of the olfactory bulb, piriform lobe and frontal cortex exclusively during paradoxical sleep (PS).
Methodology: Seventeen adult armadillos chronically prepared for electrographic recordings were employed. Some animals were subjected to VNO bilateral remove. They were studied during wakefulness and sleep phases.
Results: An outstanding phenomenon occurs during PS of armadillos submitted to bilateral ablation of the VNO. There is a dramatic change in the oscillations of the olfactory bulb electrical activity strictly confined to PS. The change consists of the sudden appearance, as soon as PS initiates, of high amplitude gamma oscillations during the whole duration of each PS episode. They disappear as soon as PS comes to an end. The oscillations are also seen in the paleocortex and the frontal neocortex. They disappear after the transverse section of the olfactory peduncles.
Conclusions: Our results show the absence of VNO deeply modifies the electrophysiological expression of PS in the olfactory bulb and other extensive brain areas. They are elicited by the centrifugal input to the olfactory bulb. From there they propagate to the piriform and frontal neocortex. These results show a new and subtle role for the organs. Some hypotheses related to the effects of bilateral removal of the VNO are presented.2023-03-01T00:00:00ZA 50 años del primer implante de un Corazón Artificial TotalCervino, Claudiohttps://repositorio.unimoron.edu.ar/handle/10.34073/3062023-02-27T17:20:28Z2019-04-01T00:00:00ZTítulo : A 50 años del primer implante de un Corazón Artificial Total
Autor : Cervino, Claudio
Resumen : El Dr. Domingo Liotta, cirujano cardiovascular y actual Vicerrector Honorario de la Universidad de Morón, es considerado un pionero en el tratamiento de pacientes con insuficiencia cardíaca avanzada. El Dr. Liotta ha creado, y utilizado en pacientes, los Sistemas de Asistencia Ventricular Izquierda en la Baylor University -en Houston, con el doctor Michael E. DeBakey-, y el Corazón Artificial Total -en el Texas Heart Institute con el doctor Denton A. Cooley-. En abril de 2019 se cumplen 50 años de la histórica cirugía en donde un hombre, desahuciado, vivió casi tres días gracias al reemplazo de su corazón biológico no funcionante con un corazón artificial, ideado y desarrollado por el propio Dr. Liotta.2019-04-01T00:00:00ZSistema de Asistencia Ventricular Izquierda: el Novel-LVAS®Cervino, ClaudioIrusta, AlfredoNasini, VíctorLiotta, Domingohttps://repositorio.unimoron.edu.ar/handle/10.34073/3052023-02-27T17:20:14Z2017-01-01T00:00:00ZTítulo : Sistema de Asistencia Ventricular Izquierda: el Novel-LVAS®
Autor : Cervino, Claudio; Irusta, Alfredo; Nasini, Víctor; Liotta, Domingo
Resumen : Se presenta el desarrollo de un Sistema de Asistencia Ventricular Izquierdo (SAVI) como puente al trasplante cardiaco y a la recuperación funcional del corazón en insuficiencia cardíaca avanzada. Consideraciones básicas en el diseño: 1) dispositivo implantable de tamaño reducido y liviano de poliuretano de grado médico; 2) sin cánulas en las cámaras del corazón; 3) atriostomía para el ingreso de sangre a la bomba implantada; y 4) se sincroniza el funcionamiento del dispositivo con el ECG del paciente. El conector de salida puede ser superior (Modelo I) o inferior (Modelo II). Una unidad electro-neumática externa genera pulsos de aire comprimido y sus parámetros de funcionamiento pueden ser programados. Ensayos in vitro muestran que durante cada ciclo la cámara sanguínea del ventrículo artificial es completamente llenada y vaciada. El rendimiento hidrodinámico muestra que trabaja bien a bajas frecuencias (55 a 65 lat.min-1); si son mantenidos constantes las presiones sistólica (200 mmHg) y diastólica (0 a -20 mmHg), de 4 a 6 L.min-1 de sangre pueden ser entregados a la circulación. Este SAVI se sincroniza con el ECG del paciente, que le permite expulsar el volumen sistólico durante la diástole y de esta manera actuar como un contrapulsador crónico.
Descripción : Abstract—The development of a Left Ventricular Assist Device (LVAD) is presented as a bridge to cardiac transplant and to functional recovery of the heart in advanced cardiac failure. Basic considerations in the design: 1) small-sized and light implantable device made of medical grade polyurethane; 2) without any cannula in the heart chambers; 3) atriostomy for the blood inflow to the pump implanted; 4) the device functioning is synchronized with the patient’s ECG. The outflow connector may be placed superiorly (Model I) or inferiorly (Model II). An external electro-pneumatic unit generates compressed air pulses and its functioning parameters may be programmed. In-vitro tests show that during each cycle the blood chamber of the artificial ventricle is completely filled and emptied. The hydrodynamic performance shows that is works well at low frequencies (55 a 65 beats per min-1) if the systolic pressure (200 mmHg) and the diastolic one (0 to -20 mmHg) are kept constant from 4 to 6 blood liters per min-1 may enter the circulation. This LVAD is synchronized with the patient´s ECB, which allows expelling the systolic volume during diastole and in this way to act like a chronic counterpulser.
Keywords—left ventricular assist device, biomaterials, cardiac failure, atriostomy, LVAD-ECG synchronization.2017-01-01T00:00:00ZOlfactory deafferentation generates gamma activity in the hippocampus during the wake-sleep cycle in the armadillo (Chaetophractus villosus)Cervino, Claudiohttps://repositorio.unimoron.edu.ar/handle/10.34073/2942022-11-16T21:16:36Z2022-01-23T00:00:00ZTítulo : Olfactory deafferentation generates gamma activity in the hippocampus during the wake-sleep cycle in the armadillo (Chaetophractus villosus)
Autor : Cervino, Claudio
Resumen : Background: There are recent evidence of sleep-dependent changes in olfactory system structure and function which contribute to odor memory and perception.
Objective: The aim of the present study is to study the effect of the elimination of the olfactory mucosa on the electrical activity of the hippocampus, olfactory bulb, olfactory tubercle, pyriform cortex and frontal cortex during wakefulness and sleep.
Methodology: Fifteen adult armadillos chronically prepared for electrographic recordings were employed in this study. Some animals were subjected to peripheral olfactory deafferentation by removal of the olfactory mucosa. They were studied during wakefulness and sleep phases.
Results: The lack of peripheral olfactory input causes invasion in all the structures mentioned by very conspicuous and almost continuous bursts of high amplitude gamma activity (32 Hz) during slow wave sleep and paradoxical sleep.
Conclusions: The hippocampus, together with some olfactory structures participates in an outstanding phenomenon produced by the suppression of olfactory receptors. The appearance of continuous bursts of gamma activity is in sharp contrast to other published studies because it is entirely independent from olfactory input. The relevance of this phenomenon is discussed considering the so called non olfactory functions of the olfactory bulb and the participation of the hippocampus in emotion, learning and memory. The importance of studying the effects of peripheral olfactory deafferentation during sleep is emphasized in view of possible derivations of interest for the interpretation of some pathological conditions. The significance of these findings is discussed.
Descripción : Article DOI: https://doi.org/10.30574/wjbphs.2022.11.1.0106 Ethical approval was obtained from ethical committee. The animals were treated following the code of ethics outlined by the Canadian Council on Animal Care and also according to the Argentine law. All efforts were made to minimize animal suffering and to reduce the number of animals used.2022-01-23T00:00:00Z